Frequently Asked Questions

Scientific evidence

The scientific publications of NESA® non-invasive neuromodulation technology as of January 2024 are as follows:

Medina-Ramírez, R.; Mallol Soler, M.; García, F.; Pla, F.; Báez-Suárez, A.; Teruel Hernández, E.; Álamo-Arce, D.D.; Quintana-Montesdeoca, M.d.P. Effects in Sleep and Recovery Processes of NESA Neuromodulation Technique Application in Young Professional Basketball Players: A Preliminary Study. Stresses 2024, 4, 238-250. https://doi.org/10.3390/stresses4020014

García F., Fernández D., Vázquez-Guerrero J., et al. (2022) Recovery of the physiological status in professional basketball players using NESA® neuromodulation treatment during different types of microcycles in season: A preliminary randomized clinical trial. Frontiers in Physiology. 2022;13. https://www.frontiersin.org/articles/10.3389/fphys.2022.1032020

Medina-Ramírez, R., Molina-Cedrés, F., Báez-Suárez, A., & Álamo-Arce, D. (2021). NESA® Non-Invasive Neuromodulation; A New Frontier of Treatment of the Autonomous Nervous System in Physiotherapy. 4.DOI: https://www.cientperiodique.com/article/CPQOS/5/4/97

Teruel-Hernández E., López-Pina J.A., Souto-Camba S., Báez-Suárez A., Medina-Ramírez R., Gómez-Conesa A. Improving Sleep Quality, Daytime Sleepiness, and Cognitive Function in Patients with Dementia by Therapeutic Exercise and NESA® Neuromodulation: A Multicenter Clinical Trial. International Journal of Environmental Research and Public Health. 2023; 20(21):7027. https://doi.org/10.3390/ijerph20217027

Báez-Suárez, A., Padrón-Rodríguez, I., Castellano-Moreno, E., González-González, E., Quintana-Montesdeoca, M. P., & Medina-Ramírez, R. I. (2023). Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation. BMC Pediatrics, 23(1), 465. https://doi.org/10.1186/s12887-023-04307-4

Contreras, M., Medina-Ramírez, R., Teruel-Hernández, E., Vílchez-Barrera, M., Báez-Suárez, A., & Álamo Arce, David. (2023). Rehabilitation in Sleep, Pain, and Bladder Symptoms of NESA® Neuromodulation Application in Multiple Sclerosis Patients: An Innovative Treatment. CPQ Medicine Journal, 15(1). https://www.cientperiodique.com/article/CPQME-15-1-439.pdf

Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce, DD. (2020). Recuperación exitosa de un Síndrome Regional Complejo a través de la electroterapia de neuromodulación del Sistema Nervioso Autónomo. 58o Congreso SERMEF. Mallorca, Spain. http://hdl.handle.net/10553/114084

Medina-Ramírez, R. (2021). ¿Los deportistas profesionales tienen una óptima calidad del sueño? Aprender a dormir, una asignatura pendiente. XXIX Reunión Anual de la Sociedad Española del Sueño, España.

Medina-Ramírez, R., Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce. Tecnología NESA®. Un nuevo tratamiento revolucionario en fisioterapia. Macaronesian Researcher`s night. In Horizonte 2020 Congress. 2020. Las Palmas, Spain.

Lledó-Amat, M., Medina-Ramírez, R., Álamo-Arce, & Arteaga-Ortiz, R. (2021). Efectos de la Neuromodulación no invasiva NESA en el tratamiento de secuelas de Ictus: A propósito de un caso. Congreso Nacional de Fisioterapia de la UMH, España.

Lledó-Amat, M., ancho-Francés, A., Medina-Ramírez, R. & Álamo-Arce, D. (2021). Tratamiento de la neuralgia del trigémino con Neuromodulación No Invasiva NESA®: A propósito de un caso. Congreso Nacional de Fisioterapia de la UMH, España.

Medina-Ramírez, R., & Román, T. (2021). Efectos de la Neuromodulación No Invasiva NESA® en el tono muscular, el dolor y el sueño, en pacientes bruxistas. Aprender a dormir, una asignatura pendiente. XXI reunión Anual de la Sociedad Española del Sueño, España.

Contreras, M., & Medina-Ramírez, R. (2021). Caso clínico de neuromodulación superficial aplicada (NESA®) en pacientes con esclerosis múltiple. Congreso de Fisioterapia Nacional UMH, España

Medina-Ramírez, R., Molina-Cedrés, F., & Moreno, A. (2022). Potenciando la fisioterapia invasiva a través del sistema nervioso autónomo. I JORNADA PRESENCIAL Fisioterapia invasiva. Barcelona, Spain.

Cano-Uceda, A. Aparicio-Montero, P. Medina-Ramírez, R. (2023) Effectiveness of non-invasive neuromodulation in improving sleep quality and stress in physiotherapy students. Multicenter study. In SPRM Congress 2023. Colombia.

Molina-Cedrés, F., González, M., & Medina-Ramírez, R. (2022). Combining physiotherapy techniques: Treatment of plantar fasciitis with NESA® neuromodulation and electrolysis. The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

Contreras, M., Medina-Ramírez, R., & Molina-Cedrés. (2022). NESA® Non-invasive neuromodulation; a chance to approach sclerosis multiple symptoms. The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

Báez-Suárez, A., Medina-Ramírez, R., Molina-Cedrés, Padrón, I., Montesdeoca, M. del P., Castellano, E., & González, E. (2022). Can microcurrents help children with neurodevelopmental disorders with their defecation and sleep quality problems? The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

Ruiz-López, K., González, M., & Medina-Ramírez, R. (2023). NESA® Neuromodulation in pelvic floor and uroginecology. I NESA Event International Conference, Madrid, Spain.

Medina-Ramírez, R.I, Molina-Cedrés, F., Báez-Suárez, A., Álamo Arce, D., & Mallol-Soler, M. (2022). Improving sleep quality: The new frontier of physical therapy neuromodulation of the autonomic nervous system. Congreso Internacional de Fisioterapia de Cataluña, Barcelona, Spain.

Báez-Suárez, A., Pestana-Miranda, R. Álamo-Arce, D. Martín-Castillo, E., Medina-Ramírez, R. (2020). Effectiveness of non-invasive neuromodulation in children with neurodevelopmental disorders to improve constipation and sleep quality. In SPRM Congress. Belgrade, Serbia.

Zamorano, E., & Medina-Ramírez, R. (2022). Face to Face. Neuromodulación percutánea versus no invasiva (sistemas inductivos de alta intensidad y NESA®). V Congreso Internacional de Fisioterapia Invasiva, Madrid, Spain.


The upcoming clinical trials scheduled for 2024 and 2025 are as follows:

1º "Efficacy of the NESA XSIGNAL® device for the treatment of anterior cruciate ligament injuries: Randomized controlled clinical trial."

Institution: Clínica Sant Josep-Althaia; Manresa, Barcelona.

Identifier: NCT05207943

Objective: To expedite the patient's recovery process following ACL surgery and mitigate associated economic costs by:

-Enhancing functionality, stability, and joint strength.-

-Facilitating pain reduction during the rehabilitation process.

-Reducing the number of lesions generated after the first 6 months post-surgery.

Type of study: Randomized double-blind clinical trial with control group.

2º PRONES Study: "Influence of NESA® medical technology on postoperative knee recovery".

Institution: Hospital San Juan de Dios de Tenerife

Authors: Castillo Rodríguez, J.C. Alfonso, T. Barrio, M.A. Domínguez, B., Álvarez, S., Fierro, I., Gil, N., Rodríguez, Y., Lugo, J., Medrano, R., García, L., Medrano, R., García, L., Fierro J.

Identifier: NCT06134999

Objective: To demonstrate that treatment with Applied Superficial Neurostimulation compared to standard treatment:

-Reduces pain both in the early postoperative phase and in the medium and long term.

-Improves health-related quality of life in the first postoperative months. -Improves functional capacity in the weeks following surgery.Improves functional capacity in the weeks following surgery.

-Reduces the time to discharge from rehabilitation.

Type of study: Randomized double-blind clinical trial with control group.

3º "Application of Non-Invasive Neuromodulation NESA® in the rehabilitation of stroke sequelae: A preliminary randomized clinical trial".

Institution: Universidad de las Palmas de Gran Canaria (Spain)

Authors: Lledó, M. Medina, R. D., Álamo-Arce, Molina, F. Báez, A. Sancho-Francés, A.

Identifier: NCT05853952

Main objective: To evaluate whether NESA® Microcurrents can be used as an effective treatment for various sequelae in stroke patients.

Secondary objectives:

-Improving spasticity.

-Improving balance.

- Improving pain.

- Improving the quality of life.

-Improve independence in activities of daily living (ADLs). Improve quality of sleep.

4º "Efficiency of NESA® microcurrents on quality of life in geriatric patients".

Institution: ULPGC (Spain), Centro Sociosanitario Queen Victoria (Las Palmas)

Authors: Báez, A. Rivero, E. Fernández, L. Domínguez, S. Báez, V. Medina, R. Vílchez, M. Identifier: NCT05800431

Identifier: NCT05800431

Main objective: To evaluate the changes in health-related quality of life in elderly patients after the application of NESA® Non-Invasive Neuromodulation.

Secondary objectives:

-Assessing sleep quality.

-Analyze changes in the levels of depression.

5º "Efficacy of non-invasive neuromodulation in the treatment of post-coital sequelae-19".

Institution: University of Cordoba

Authors: León, G. R., Medina-Ramírez, R. Molina, F.

Main objective: To test the efficacy of NESA® Non-Invasive Neuromodulation as a therapy in neurological, respiratory, and musculoskeletal pathologies derived from the sequelae of COVID-19.

Secondary objectives:

To improve the functionality and quality of life of patients with sequelae of COVID-19.

6º "Usefulness of NESA® Microcurrents in the treatment of sleep disturbances, disruptive behaviors in children with autism spectrum disorder (ASD) and in the quality of life of the family unit. Randomized controlled clinical trial".

Institution: Hospital Universitario de Gran Canaria Doctor Negrín

Authors: Báez Suarez, A., Vílchez-Barrera, M., Padrón Rodríguez, I., Lozano Céspedes, I., Álamo Rincón, K., Martín Pérez, A., Etoopa Bitata, M., Hernández, A.

Main objective: To test the influence of NESA® surface neuromodulation on sleep disturbances in children with autism spectrum disorders.

Secondary objectives:

-To analyze the influence of NESA® surface neuromodulation on the different aspects of sleep in children with autism spectrum disorder.

-To study the influence of NESA® surface neuromodulation on the relationship between sleep and the presence of disruptive behavior in children with autism spectrum disorder.

-To test the relationship between the possible improvement of sleep disorders produced by superficial Neuromodulation applied with NESA® and the quality of life of the child and his/her family.

7º "Efficacy of the application of NESA® Microcurrents in patients with ischemic heart disease and moderate LVEF (<50%) within a conventional cardiac rehabilitation program".

Institution: Hospital Rey Juan Carlos. Universidad Europea

Authors: Villanueva, M., Bermejo, A., Media-Ramírez, R.

Objectives:

-To improve the patient's tolerance to exertion.

-Influencing the patient's autonomic nervous system.

-Increasing cardiac ejection rate.

-Improving cardiac variability in patients with ischemic heart disease.

-Improving the patient's quality of life.

Type of study: Prospective, longitudinal, analytical, randomized clinical trial.

8º "Efficacy of NESA® microcurrents in the treatment of sleep problems, fatigue, and neuromuscular pain in cancer survivors. Randomized double-blind clinical trial".

Institution: ULPGC (España)

Authors: Amengual-Jaume, G., Medina -Ramírez. R., Álamo-Arce, D., Arteaga-Ortiz, R., Báez-Suárez, A., Molina F.

Main objective: To determine the efficacy of NESA® Microcurrents as a treatment for sleep problems, fatigue, and neuromuscular pain in cancer survivors.

Secondary objectives:

-Improving sleep quality.

- Improving pain.

9º "Analysis of the promotion and/or intervention of sleep health regulation in the workplace".

Institution: Clínica Antonio Gaspar- Fisioterapia y rendimiento

Authors: Cristina Vidal, A., Gaspar, A., Valeriano, J.

Main objective:

-Improving workers' sleep.

-Reducing the application time of the NESA® clinical sleep regulation protocol, to enable its application in the work sector.

Secondary objectives:

-To validate the application of NESA® Microcurrents to contribute to the development of healthy work, in the labor sector, with translation to other sectors of industry and similar.

10º "Efficacy of NESA XSIGNAL® neuromodulation versus transcutaneous posterior tibial stimulation for the treatment of overactive bladder. Randomized controlled clinical trial"

Institution: University of Valencia (Spain)

Authors: Blasco Bonora, P., Pardo-Sievers, B., Fuentes, L., Medina-Ramírez, R.

Objective: To evaluate the efficacy and safety of the application of NESA XSIGNAL® medical technology in the treatment of patients with overactive bladder to improve the mechanism of bladder function regulation and thus the patients' symptoms and quality of life.

11º "Efficacy and safety of NESA XSIGNAL® applied surface neurostimulation technology for the treatment of complex regional pain syndrome (CRPS) type I".

Institution: MAZ Hospital of Zaragoza

Authors: Dr. Roque, Báez, A.

Identifier: NCT05052736

Objectives: To evaluate the patient's recovery process and pain modulation, shortening the recovery time and economic costs associated with complex regional pain syndrome type I.

Type of study: Randomized, open-label, parallel, controlled clinical trial.

12º "Efficacy of Non-Invasive Neuromodulation NESA® through somatosensory evoked potentials and sympatho-cutaneous responses in healthy subjects: feasibility study in physiotherapy".

Institution: University of Las Palmas de Gran Canaria, Clínica M, Fisioterapia Daniel Reig (Jaén)

Identifier: NCT04962737

Somatosensory evoked potentials are crucial for determining physiological changes of potentials in nerve pathways. Although their main function is diagnostic, they have recently been used as a physiological test to determine physioelectric changes in healthy subjects to study applied stimuli such as laser, pain or electrotherapy.

Objectives: The aim of this study is to determine whether there are changes in the somatosensory evoked potentials of the ulnar, median, tibial, peroneal, and vagus nerves when applying NESA® non-invasive neuromodulation, which is used as a physiotherapeutic treatment for purposes such as pain, vegetative disorders, and sleep dysfunctions.

There are numerous scientific and academic agreements in place with universities and institutions. Below, you'll find an audiovisual compilation of these agreements:

1º [ES][ES] WATCH VIDEO 1st Agreement with the University of Health Sciences of Las Palmas de Gran Canaria

2º (EN) WATCH VIDEO Agreement with the European University of Madrid

3º [ES] [ES] WATCH VIDEO Agreement with the Castilla de la Mancha University of Health Sciences

4º [ES][ES] WATCH VIDEO Agreement with the University of Health Sciences Alfonso X el Sabio, Madrid, Spain

5º[ES] [ES] WATCH VIDEO Agreement with the University of Health Sciences of Alcalá de Henares, Madrid, Spain

6º (EN) WATCH VIDEO Rey Juan Carlos I University, Madrid, Spain

7º (EN) WATCH VIDEO Agreement with the Innovation HUB of FC Barcelona

8º (EN) WATCH VIDEO Agreement with Sant Josep Althaia Clinic, Manresa, Spain

9º (EN) WATCH VIDEO Agreement with Quirón Tenerife Clinic and Hospital Insular Materno Infantil, Canary Islands, Spain

10º (EN) WATCH VIDEO Agreement with the San Juan de Dios Hospital of Tenerife, Spain

11º (EN) WATCH VIDEO Agreement with the San Juan de Dios School of Las Palmas de Gran Canaria, Spain

12º (EN) WATCH VIDEO Agreement with the Hospital de Accidentes Laborales MAZ of Zaragoza, Spain

In addition to the agreements recorded audiovisually, the following agreements are currently active:

- University of Abu Dhabi

- UAE University of Sinu, Colombia

- University of Parma, Italy

- University of Cordoba, Spain

- University of Murcia, Spain

In the realm of research concerning NESA® medical technology, significant attention has been directed towards its impact on the hormonal system, particularly focusing on key hormones such as cortisol and testosterone, alongside important biomarkers like creatine kinase (CK). This emphasis has been especially prominent within the realm of sports, where hormone equilibrium plays a pivotal role in both performance and recovery.

The interest in this domain stems largely from the notable influence exerted by the autonomic nervous system on hormone regulation. Given this intricate interplay, investigations into how NESA® affects endocrine disorders and hormonal fluctuations have emerged as areas of considerable interest and growth.

Looking ahead, this field of inquiry is anticipated to expand, offering fresh insights into novel avenues for comprehending and addressing various conditions linked to the endocrine and hormonal systems. It represents a promising domain that continues to evolve, holding promise for significant advancements in the days to come.

Yes, we recommend that you visit the training and events section as well as the NESA® Non-Invasive Neuromodulation lectures section.

For accredited research groups:

If you lead or are part of an accredited research group and are interested in collaborating in NESA® Non-Invasive Neuromodulation studies, we invite you to contact us. Please use our contact form to introduce your research group. Be sure to include details such as your group's website, outstanding references, areas of expertise you are interested in, and a summary of why you would like to collaborate with us. Your application will be reviewed by our senior research team at the University of Health Sciences of Las Palmas de Gran Canaria, who will facilitate the necessary discussions to establish a scientific agreement. We are proud to mention that we currently have agreements with more than 15 universities around the world and collaborate with more than 8 independent hospital research groups.

For clinical health professionals:

If you are a clinical healthcare professional interested in developing a research project on NESA® medical technology, but do not have extensive scientific experience, it is important that you already have clinical experience with our technology. We are looking to collaborate with clinics that demonstrate sound clinical reasoning and a thorough understanding of the clinical results obtained with the use of our device in daily practice. If you meet these criteria, we encourage you to contact your account manager or distributor to submit your research proposal by email. Your proposal should include the type of research, the number of patients involved, the specific objectives, among other relevant details. Our research department at the University of Health Sciences of Las Palmas de Gran Canaria will evaluate your proposal. If it is of interest, we will contact you to discuss the next steps and potentially add your project to our list of running projects.

Contact

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