Frequently Asked Questions

Technical questions

When a hospital or clinic acquires the NESA XSIGNAL® Non-Invasive Neuromodulation medical technology, the following components are included:


  • NESA XSIGNAL® Device
  • CEXT-N Extension Cable Set (4 pieces, color-coded: blue, red, green, and yellow)
  • CONTACT-NC Button Cable Set with 6 Contacts (color-coded: blue, red, green, yellow, white, and black)
  • GDCN Cable (1 piece)
  • Dermal Electrodes (2 bags)
  • Set of Non-Compressive Gloves and Anklets (Sizes S, M, L)
  • Set of Compressive Gloves and Anklets (Sizes S, M, L)
  • NESA XSIGNAL® PWR Power Supply with Country-Specific Adapters
  • Heavy-Duty Transport Case for the XSIGNAL® Medical Device
  • XSIGNAL® Device Transport Backpack
  • Instruction Manual
  • Timer
  • Adapted Furniture with Casters for the XSIGNAL® Medical Device
  • Wecardio ECG Event Recorder (Portable Electrocardiogram)
  • Tablet Holder Adapted for the Furniture
  • Spike Tool for Disconnecting Electrodes from Gloves and Anklets
  • Training Kit
  • Box 3 Information Material (includes Android tablet, digital frame, and USB containing all digital and audiovisual materials)
  • Clinic Kit (includes roll-up explaining the technology, authorized center circle, and neural synapse vinyl, 120 cm x 180 cm)

WATCH VIDEO: Discover the XSIGNAL: Exclusive Unboxing with Fabiola Molina:


Online campus clinical guides: This resource includes six hours of basic introductory training to provide comprehensive foundational knowledge on its usage. Additionally, there are over 24 hours of didactic audiovisual materials covering topics such as neuroanatomy, physiology, clinical reasoning, clinical cases, integration with therapies, scientifically validated patient assessments, and more.

(EN) WATCH VIDEO: Basic introductory online campus of Neuromodulation Non Invasive NESA®

[ES] WATCH VIDEO: NESA® Clinical Guidelines Campus

Online University Expert in Non-Invasive Neuromodulation NESA® of the University of Health Sciences of Las Palmas de Gran Canaria: 150 hours of content, 12 webinars in Spanish and English with 12 expert professors present in the forums and webinars.

(EN) WATCH VIDEO: Online University Expert in non-invasive neuromodulation NESA®

The Autonomic Nervous System Readaptation Treatment Units (RSNA) represent an innovative approach to wellness, focusing on the integrative harmonization of the patient's autonomic nervous system. This integrative approach includes:

  • Optimal Comfort: We ensure maximum comfort with specialised NESA® treatment chairs.
  • Visual and Light Stimuli: We create a visually soothing environment with carefully selected color tones and screens that display calming images.
  • Sound Environment: We offer a serene listening experience, available either through the ambient sound of the room or via soundproofed headphones.
  • Olfactory Stimuli: We enhance the experience with a scent dispenser, utilizing essential oils to create a pleasant olfactory environment.
  • Neuromodulation Technology: We utilize NESA® Non-Invasive Neuromodulation technology, supported by expertise acquired through our official training programs.

What is the NESA Clinics concept?

NESA Clinics is a clinical concept featuring one or several areas dedicated to the rehabilitation of the autonomic nervous system. These spaces not only equip treatment rooms with an integrative wellness approach but also implement a comprehensive clinical procedure that includes:

  • Detailed Anamnesis: We assess critical aspects of the patient's autonomic nervous system, such as sleep quality, stress levels, and the presence of chronic pain.
  • Assessment Tests: We perform comprehensive assessments using tools like the Wecardio ECG and the Pittsburgh Test for accurate diagnosis.
  • Continuous Monitoring: At each treatment session, we apply a set of 5 to 10 quick questions, allowing effective monitoring of the patient's progress in just 2 minutes.
  • Post-Treatment Evaluation: After the first 10 sessions, we conduct a detailed assessment of the patient to ensure the effectiveness of the treatment and make necessary adjustments.

At NESA Clinics, we are committed to providing exceptional, personalized care based on the most advanced medical technology and expertise in autonomic nervous system care, ensuring a unique and deeply regenerative treatment experience.

[ES] [ES] WATCH VIDEO NESA Clinics Madrid: NESA Passive Treatment BOX II - Example at the MM Clinic Boadilla del Monte.

[ES] [ES] WATCH VIDEONESA Clinics Barcelona: NESAclinics Treatment Box, David Costa

[EN] [EN] WATCH VIDEO NESA Clinics Netherlands: Non-Invasive Neuromodulation Treatment box, Fyzzio ft. NESA® WORLD NESA WORLD®

[EN] [EN] WATCH VIDEO NESA Clinics Switzerland: Non-Invasive Neuromodulation Treatment Box, RATIO ft. NESA® WORLD NESA WORLD®

The application of NESA® Non-Invasive Neuromodulation in daily clinical practice is a carefully designed process to ensure maximum efficacy and patient comfort. Here, we guide you through every step of the procedure:

Patient preparation:

Before starting, it is essential to correctly attach the gloves and anklets, which must be connected to the extension leads. In addition, it is crucial to connect the ECG electrode to the ECG cable, which in turn is connected to the NESA XSIGNAL® medical technology. It is important to remember that, if the electrode array is not attached, the technology will not have any therapeutic effect. The directional electrode is disposable and single use per session.

Verification of placement:

Check that gloves and anklets are correctly positioned according to the right hand, left hand, right foot, and left foot references, and ensure that they are in the correct position.

First session and explanation to the patient:

If it is the first session, it is crucial to explain to the patient that they are unlikely to feel any physical sensation during the treatment. To help relax the patient and ensure their comfort, make an analogy by explaining that their body runs on electricity. In addition, perform a feedback test with the Wecardio electrocardiogram to demonstrate the effectiveness of the treatment.

Viewing of the instructional video:

We invite you to watch our instructional video, available in both English and Spanish, which demonstrates a 10-second Wecardio test. This video will enhance your understanding of the processes and technology behind NESA® Non-Invasive Neuromodulation.

(EN) WATCH VIDEO Correct positioning of the NESA XSIGNAL® medical device in the clinic

(EN) WATCH VIDEO How to use the WeCardio with NESA®

Evaluation of the autonomic nervous system:

After the initial 10-second test, a 5-minute recording is made to assess the autonomic nervous system (ANS) using the Wecardio Heart Rate Variability (HRV) system. Subsequently, a second HRV electrocardiogram recording is conducted post-session with the NESA® Non-Invasive Neuromodulation technology to evaluate the treatment effects.

(EN) WATCH VIDEO How to perform an electrocardiogram with the WeCardio, Dr. Pedro Serrano, cardiologist

(EN) WATCH VIDEO How to use Wecardio Part 1 - Raquel Medina

(EN) WATCH VIDEO How to use WeCardio II, Berni Machío, NESA® University Expert

By following these steps, we ensure an effective and safe application of NESA® Non-Invasive Neuromodulation in daily clinical practice, consistently aiming to enhance the quality of life for our patients.

Recommendations for patients prior to passive treatment:

The NESA XSIGNAL® neuromodulation medical device represents a significant advancement in the field of electrotherapy. Its non-invasive, painless, and imperceptible design renders it a comfortable and effective treatment option. To ensure maximum treatment efficacy, it is essential to adhere to the following recommendations:

Treatment Time as Relaxation:

View your treatment sessions as opportunities for relaxation and personal enjoyment. This period should be dedicated to focusing on your wellbeing and recovery.

Avoid Electronic Devices:

Refrain from using mobile phones or any portable electronic devices during therapy sessions. The electromagnetic waves emitted by these devices may disrupt the microcurrents induced by the treatment. Furthermore, disconnecting from digital technology fosters a deeper state of relaxation, thereby enhancing the therapeutic outcomes.

Engage in Relaxing Activities:

Prefer activities that do not involve electronic devices, such as reading a book. These alternatives promote relaxation and do not interfere with the effectiveness of your treatment.

Listen to Relaxing Music:

Introduce relaxing music, such as binaural beats or nature sounds, into your treatment sessions to further enhance your recovery experience.

Remove Jewelry and Metals:

To ensure the efficacy of your treatment, remove all metallic items like watches and jewelry. The XSIGNAL® medical device operates using the electrical impedance properties of the skin, and metals can alter these properties, leading to distorted signals.

During Active Therapy:

The guidelines also apply if your therapy session is active. During these sessions, you will likely be reclined on a stretcher, and the healthcare professional will be actively involved in administering your treatment. Collaboration and adherence to your therapist’s instructions are crucial for maximizing the therapeutic benefits.

By following these recommendations, you can maximise the benefits of your NESA XSIGNAL® treatment, enjoying a more relaxing and effective therapeutic experience.

The choice between passive and active therapy using NESA® Non Invasive Neuromodulation technology is based on a number of clinical factors and the specific working dynamics of each clinic and its healthcare professionals. The following guide provides insights into when each type of therapy may be recommended:

Passive Therapy:

Objective: Passive therapy is aimed at delivering a relaxing and non-invasive treatment experience, requiring no active participation from the patient beyond simply relaxing and receiving treatment.

Recommended for: This mode is suitable for patients seeking a tranquil and less demanding treatment experience. It is particularly beneficial for those who can gain from neuromodulation without active engagement, such as individuals suffering from chronic pain, sleep disturbances, stress, anxiety, overactive bladder, or fatigue.

Active Therapy:

Objective: Active therapy involves more direct engagement from the patient and/or the health professional during the treatment session.

Recommended for: This approach is tailored for patients who need a more intensive and targeted treatment for specific conditions. It proves especially effective in physical rehabilitation within manual therapy settings, combining neuromodulation with therapeutic exercises to amplify the outcomes. It is also valuable for neurologists, psychiatrists, clinical psychologists, and speech therapists engaged in psychosomatic and cognitive behavioral interventions.

Clinical considerations:

- The decision to employ passive or active therapy should be based on the individual therapeutic goals, the patient’s health status, and the guidance provided by the clinical team.

- It is crucial to highlight that the personalization of treatment is essential for maximizing the benefits of NESA® Non-Invasive Neuromodulation.


For a more comprehensive understanding of how passive and active therapies can be tailored to meet your specific needs or those of your patients, we encourage you to consult our clinical FAQs. Within these resources, you will find detailed information on each treatment modality and guidance on integrating them into treatment plans for various conditions.

Numerous tools are available to explain to patients how our nervous system functions and the mechanism of microcurrents, adapted to various understanding levels and included in our after-sales documentation. The Wecardio electrocardiogram is particularly effective: the 10-second test, which involves turning the device off and on, helps patients objectively understand the current flowing through their body without feeling it.

(EN) WATCH VIDEO How to use the WeCardio, 10-second test

It is crucial to establish baseline records before initiating treatment to objectively monitor the patient's progression, particularly in cases of chronic pathologies and conditions related to dysautonomia.

Typically, non-medical healthcare professionals feel more confident administering active treatments that combine multiple therapies, introducing the technology as a supplementary tool to their usual practices or those with which they are more familiar. The most crucial aspect is the anamnesis and identifying patients who are suitable for NESA® Non-Invasive Neuromodulation. This involves asking all patients about the state of their autonomic nervous system, with questions regarding their sleep quality, bathroom habits, anxiety levels, whether they are under care for chronic pain, and if they experience fatigue. Based on these assessments, they might be advised to undergo passive sessions using NESA XSIGNAL® medical technology. As with any professional advancement that incorporates improvements, the beginning is always crucial. Publicity plays a significant role in raising awareness; hence, the company provides both physical (roll-ups, brochures, digital frames) and digital materials for use on social networks or display screens upon the purchase of the device. Customers have access to all 3D audiovisual content, including examples available on our official Instagram account, @nesaworldofficial, which boasts over 300,000 followers. This 3D content is essential for patient education.

Choose to Read a Book or Engage in Non-Electronic Activities:

Engaging in activities that do not involve electronic technology can aid relaxation without interfering with your treatment.

Listen to Relaxing Music:

Introduce relaxing music, such as binaural beats or nature sounds, into your treatment sessions to further enhance your recovery experience.

Remove Jewelry and Metals:

To ensure the efficacy of your treatment, remove all metallic items like watches and jewelry. For optimal treatment efficiency, remove any watches, pendants, and costume jewelry. The XSIGNAL® medical device operates using the electrical impedance properties of the skin, and the presence of metals can alter this impedance, distorting the device's signals.

During Active Therapy:

The guidelines also apply if your therapy session is active. During these sessions, you will likely be reclined on a stretcher, and the healthcare professional will be actively involved in administering your treatment. Collaboration and adherence to your therapist’s instructions are crucial for maximizing the therapeutic benefits.

By adhering to these recommendations, you can maximize the benefits of your treatment with the NESA XSIGNAL® medical device, ensuring a more relaxing and effective therapeutic experience.

Here is a detailed guide on how to carry out passive therapy effectively:

Anamnesis Focused on the Autonomic Nervous System:

Begin with a comprehensive history-taking that includes relevant aspects of the patient's autonomic nervous system. This approach will help to customize the treatment to meet specific needs.

Objective assessments:

Perform objective assessments of the autonomic nervous system to facilitate clinical follow-up. These assessments may include measurements of cortisol and amylase, scientifically validated tests, ANS electrocardiograms, and the use of home autonomic assessment devices such as actigraphy before initiating treatment.

Removal of metals:

Ask the patient to remove, as far as possible, any metal on the hands and neck, such as jewellery, necklaces, bracelets, and watches, to avoid interference with the therapy.

Preparation of the laying area:

Clean the areas where the electrodes will be placed (feet, hands, and the area of the directional electrode) using alcohol and cotton wool to ensure optimal conductivity.

Position of the patient:

If on a stretcher, make sure the patient is in the supine position (lying on the back) or sitting comfortably in a good chair. If on a stretcher, use a half-roller or roller to relax the popliteal area.

Relaxing atmosphere:

We recommend covering the patient and dimming the ambient lighting, if possible, to foster a state of deep relaxation during the treatment.

Recommended sections in the FAQs

Autonomic Nervous System Readaptation Treatment Units:

Explore this section to learn how passive therapy using NESA® technology can be integrated into autonomic nervous system retraining programs, providing a comprehensive and personalized approach to treatment.

NESA Clinics concept:

Discover the unique approach of the NESA Clinics concept, where non-invasive neuromodulation is integrated with a multidisciplinary treatment strategy for various conditions, thereby maximizing therapeutic benefits for patients.

By adhering to these recommendations, you can enhance the application of passive therapy using NESA® medical technology, ensuring an effective, comfortable, and highly personalized therapeutic experience for your patients.

To ensure effective implementation and to fully leverage the benefits of this advanced technology, please adhere to the following recommendations:

Initial assessment:

It conducts a comprehensive patient assessment to determine the most appropriate combination of therapies. NESA® medical technology can be effectively integrated with various techniques, including manual and psychosomatic therapies.

Integration of Therapies:

NESA® medical technology is combined with selected manual or psychosomatic techniques. When active exercises are included, they should be of minimal load to complement the therapy without overburdening the patient.

Strategic Application of NESA® Technology:

NESA® technology is applied in a focal, metameric, or central manner, tailored to the therapeutic approach. The placement of the ECG electrode and lead is carefully managed to ensure that they do not interfere with the combined therapy.

Flexibility and Comfort During the Session:

Cables can be disconnected and reconnected to facilitate changes in the patient’s position during the session. This flexibility allows the session to be customized to the treatment needs without compromising the effectiveness of the technology.

Consultation of Clinical Doubts:

For any inquiries or additional information regarding the application of NESA® technology in specific clinical settings, healthcare professionals are encouraged to consult the clinical questions section in our FAQs. This resource offers further guidance.

Additional Advice:

Personalization of Treatment:

The flexibility of NESA® technology enables customization of treatments to meet the individual needs of each patient, thus optimizing therapeutic outcomes.

Creating an Appropriate Environment:

It is crucial to ensure that the therapeutic environment is conducive to exercise or movement, facilitating an active and effective treatment experience.

Active therapy with NESA® technology provides a unique opportunity to integrate non-invasive neuromodulation with a personalized therapeutic approach.

*For more detailed information, please refer to the Clinical FAQs.

Here are brief descriptions for each video on the installation and use of NESA XSIGNAL® medical technology:

NESA XSIGNAL® medical technology programming: Learn how to program your NESA XSIGNAL® medical device to optimize treatment protocols.

(EN) WATCH VIDEO XSIGNAL® programming. Switching on and programming

Cabling in NESA XSIGNAL® medical technology: Find out how to correctly place cabling in your NESA XSIGNAL® medical device to ensure optimal performance.

(EN) WATCH VIDEO: Colocación de cableado en XSIGNAL®

Maintenance of NESA XSIGNAL® medical technology cables: Keep your cables in perfect condition with these long-term maintenance tips

(EN) WATCH VIDEO: NESA XSIGNAL® medical technology cable maintenance: Keep your cables in perfect condition with these long-term maintenance tips

Attaching gloves and anklets to NESA XSIGNAL® medical technology cables: Step-by-step guide to connect gloves and anklets to the NESA XSIGNAL® medical device.

(EN) WATCH VIDEO:Attaching gloves and anklets to NESA XSIGNAL®

Fitting the patient with NESA XSIGNAL® medical technology gloves and anklets:Learn the correct way to place gloves and anklets on the patient for therapy.

(EN) WATCH VIDEO: Placing NESA XSIGNAL® medical technology gloves and ankle braces on the patient

NESA XSIGNAL® medical technology power supply: Important information about the battery charger and how to use it correctly in the NESA XSIGNAL® medical device.

(EN) WATCH VIDEO: Fuente de alimentación del XSIGNAL®

NESA XSIGNAL® Medical Technology Protective Case: Protect your NESA XSIGNAL® medical device with its uniquely designed magnetic protective case

(EN) WATCH VIDEO: NESA XSIGNAL® Medical Technology Protective Case

These brief descriptions and links to videos provide an overview of how to install and maintain NESA XSIGNAL® medical technology, ensuring its effective and long-lasting use.

NESA XSIGNAL® medical technology is versatile and adaptable, making it suitable for a wide range of patients, including those with amputations, malformations, or smaller limbs, such as children. Below, we will detail the methods for making these adaptations.

Adaptations for amputations or malformations:

For patients with amputations or malformations, gloves and anklets can be adjusted to be placed more cranially, aligning with the neuroanatomy of the peripheral nerves. This adjustment ensures that neuromodulation is effectively targeted to the desired areas, enhancing the therapeutic benefits of the NESA XSIGNAL® medical technology.

Use in children with small limbs:

In cases where children or patients with small extremities find the 'XS' size too large, specific modifications can be made to ensure adequate and comfortable contact. These adjustments may include altering gloves and anklets or employing special adapters designed to accommodate smaller sizes.

NESA WORLD® Limited Commercial Warranty:

All NESA XSIGNAL® modulators distributed by NGS Health and Mind SL in Spain and Europe include a limited commercial warranty at no additional cost. This warranty guarantees that the device is free from defects in components and craftsmanship from the time of its original purchase by the end user.

Duration of the warranty:

The warranty is valid for twenty-four (24) months from the original purchase date, requiring the original invoice or receipt as proof of purchase.

Storage warranty:

It is guaranteed to be stored for 52,000 hours in the warehouse from its date of manufacture.

Warranty coverage:

The warranty covers the repair or replacement of defective systems or parts with new or refurbished systems or parts that perform comparably to new products, including the cost of parts and labor.

CRU (Customer Replaceable Units) parts:

Certain components can be replaced by the customer. These parts, identified as CRU, may be shipped directly to the end user at the discretion of NESA WORLD®.

The durability of the NESA XSIGNAL® medical device is engineered to meet the highest standards of quality and performance in the medical field. NESA WORLD®'s limited commercial warranty underscores the company's dedication to reliability and customer satisfaction, guaranteeing proper device functionality and freedom from defects throughout the warranty period.


  • Any claim under this limited warranty must be submitted within twenty-four (24) months of its effective date.

  • Systems or components repaired or replaced under this warranty will remain covered for the remainder of the original warranty period or for an additional three (3) months if the remaining period is less than ninety (90) days.

  • The warranty and durability of the NESA XSIGNAL® medical device are designed to offer peace of mind and confidence to users, ensuring continuous support and service for their investment in health and wellness.

Health certification and CE marking:

The NESA XSIGNAL® Non-Invasive Neuromodulation medical technology is certified in accordance with the CE marking directive 93/42/EEC. This certification ensures compliance with the safety and performance standards mandated for medical devices within the European Union. Verification of this certification can be done through the notified body IMQ, with their database of certified products accessible at: IMQ Certified Products Database.

International certifications:

In addition, NESA XSIGNAL® medical technology has been internationally certified for quality and safety in a few countries, including:

MOHAB: United Arab Emirates

ANVISA: Brazil

INVIMA: Colombia


European adaptation in Switzerland

European adaptation in Estonia

Ongoing certification processes:

NESA XSIGNAL® medical technology is in the process of obtaining certification in several countries and regions, including:

MDR (EU Medical Device Regulation)

FDA & MDSAP (United States and the Medical Device Single Audit Program)


Australia and New Zealand



Costa Rica





ISO 13485 standard for medical device manufacturers:

NGS Health and Mind SL, the company behind the NESA XSIGNAL® medical device, adheres to ISO 13485. This internationally recognized quality management standard is specifically tailored for manufacturers of medical devices. It sets forth essential requirements to ensure the quality of manufactured medical devices, showcasing the company's dedication to excellence and the safety of its products.

Commitment to quality and safety:

Adherence to these regulations and the attainment of multiple international certifications underscore NESA WORLD®'s dedication to the quality, safety, and efficacy of its non-invasive neuromodulation technology. These credentials provide assurance to users and healthcare professionals alike, demonstrating that they are utilizing medical technology supported by rigorous standards and certification processes.

NESA XSIGNAL® Medical Technology Care and Use Guidelines

Aftercare and preparations

Cleaning of Accessories: It is crucial to clean gloves and anklets after each use, preferably with hydroalcoholic gel or alcohol-soaked cotton wool. While we strongly recommend that each patient has their own set for hygiene purposes, this measure becomes essential if accessories are shared.

Skin Preparation: Before attaching the ECG, ensure it is designated for single use only per patient per session. For areas with hair, shaving is recommended to facilitate effective contact.


Instructions for Domestic Use:

While no specific training is required for private use of the device, we recommend monthly clinical monitoring by a NESA® Non-Invasive Neuromodulation expert.

Conditions of Use:

  • Avoid using the device in wet environments or submerged in water.
  • Begin stimulation in a comfortable position, preferably sitting or lying down, to prevent initial feelings of weakness.
  • Keep the device away from shortwave, microwave, or high-frequency surgical equipment to prevent irritation or burns.
  • Do not disconnect the cables during a session without first switching off the device.
  • Refrain from using the device if it is damaged or if its casing is open.

Specific precautions

Storage and access:

Store the device and its accessories out of the reach of children and ensure that no foreign objects get into the device.

Care of the Device:

Protect the device from sudden temperature changes to avoid affecting its performance. Ensure it is positioned for easy disconnection from the power supply.

Electrode Maintenance:

- Hygiene: Each user should have their own set of electrodes to prevent health risks.

- Electrode Use: Do not reuse dermal electrodes more than once to maintain contact quality and adhesion.

- Sensitive Skin: If red spots appear after stimulation, wait until they disappear before continuing with sessions.

Additional Recommendations:

- Consult the Manual: For correct electrode placement or in case of doubt, refer to the user manual or contact NESA WORLD®.

- Suitable Accessories: Use only electrodes and accessories provided by NESA WORLD® for effective and safe treatment.

By following these guidelines, users of the NESA XSIGNAL® medical device can confidently deliver safe and effective neuromodulation treatment.

*For very important hygienic reasons, each user must have his own set of electrodes. Refrain from using the same electrodes with different people.

* Do not use the same set of dermal or compatible electrodes for more than one session, as the quality of the contact between the electrode and the skin – an important factor in the comfort and effectiveness of the stimulation – gradually deteriorates. In addition, adhesion is lost, and if it comes off the skin, the system has no effect. If in doubt, please consult the manufacturer according to electrode models.

* In individuals with very sensitive skin, red spots may appear under the electrodes after a stimulation session. Generally, these red spots are completely benign and will disappear shortly. However, stimulation sessions should not be resumed if the red spots have not disappeared.

NESA XSIGNAL® medical technology comprises various components and accessories meticulously crafted to enhance the neuromodulation experience. These parts possess varying levels of durability and undergo refurbishment according to their usage and care.

Compression gloves and anklets: Average durability of 12 to 18 months.

Elasticated gloves and anklets: Average durability of 8 to 12 months.

Extension and routing cables: Average durability of 2 to 5 years.

Dermal ECG electrodes: Single use per session.

Power supply: Average durability of 2 to 5 years.

Other components: This category encompasses stationary items, furniture, tablets, digital frames, etc.

To purchase spare parts, you can reach out to your account executive, call the head office at: +34 943 44 35 45 45, or contact authorized distributors in your respective country.

Review and Verification:

It is advisable to perform a connectivity check with the current meter on an annual basis.

A complete overhaul of the device at NESA WORLD® headquarters is ideal every one to two years, to ensure optimum performance.

Recommended maintenance:

Keep equipment and accessories clean, using a damp cloth and/or alcohol wipe for cleaning.

Before attaching the accessories, clean the skin where the skin calluses will come into contact with alcohol.

If the glove and/or ankle socks have a rusty black colour or appearance, it is time to replace them. New glove and ankle sets are available from NESA WORLD®.

These maintenance and servicing guidelines ensure that your NESA XSIGNAL® medical device maintains its efficacy and safety, providing an optimal and long-lasting neuromodulation experience.

Compressive models:

Ref.: GT0002 - Size S

Ref.: GT0003 - Size M

Ref.: GT0004 - Size S

Elastane models:

Ref.: GT0005 - Size XS1

Ref.: GT0006 - Size XS2

Ref.: GT0007 - Size S

Ref.: GT0008 - Size M

Ref.: GT0009 - Size L

Ref.: GT0010 - Size XL

Technical Differences:

Compressive: Designed to provide uniform pressure, enhancing conductivity and neuromodulation efficacy. Average durability of 12 to 18 months with daily use of 6 to 8 hours.

Elastane: Offers greater flexibility and comfort, ideal for accommodating various sizes and shapes of limbs. Average durability of 6 to 8 months with daily use of 6 to 8 hours.

Use and Maintenance:

Can gloves and anklets be shared between patients?

It is highly recommended that each patient has their own set of gloves and anklets, stored in a bag identified for each patient. However, they can be used by different patients if subjected to optimal washing and hygiene processes.

How are gloves and anklets washed?

Gloves and anklets can be washed in warm water at 30°C in a washing machine, placed in a protective bag, or soaked with neutral soap in warm water.

How long do gloves and anklets last?

Compression gloves and anklets have an average durability of 12 to 18 months, while elastane models last approximately 6 to 8 months, both with daily use of 6 to 8 hours.

Is it possible to use compressive and elastane models on different limbs?

Yes, it is advisable to use compressive gloves on the hands and elastane models on the feet for greater comfort and ease of application daily.

These options and recommendations ensure that users of NESA XSIGNAL® medical technology can select the most suitable accessories for their needs, ensuring a comfortable, effective, and personalized neuromodulation experience.

(EN) WATCH VIDEO Possible treatments with NESA® medical technology

Key information about the CEXT-N electric extension cables and short contact - NC extension cables.

Types and References:

Ref.: C0009 - CEXT-N Long Extension Cable (Left foot, yellow colour)

Ref.: C0010 - CEXT-N Long Extension Cable (Right foot, green colour)

Ref.: C0011 - CEXT-N Long Extender Cable (Left hand, blue colour)

Ref.: C0012 - CEXT-N Long Extender Cable (Left hand, red colour)

Main Features:

Length: Each cable measures 30 centimetres.

Connectors: Equipped with a safety system for quick disconnection. The snap button connectors are colour and numerically coded for ease of use.

Emitters: Each cable has 6 microcurrent pulse emitters.

Frequently asked questions about its use

Is it possible to disconnect the cables during a session?

Yes, the cables can be temporarily disconnected, for example, to change the patient's position or for a short break. This does not affect the function of the device if the disconnection is for a short period of time.

What happens if I connect the cables in the wrong colours?

It is important to check the correct connection of the cables before starting the session. The colours of the cables must match the indications on the XSIGNAL® medical device, the instruction manual and the included training content. An error in connection may result in a lack of clinical benefit or minor adverse effects, such as headache or fatigue. We recommend following the instructions carefully to avoid confusion.

What to do if the colours of the connection buttons of gloves and anklets are confused?

Before starting the session, make sure that the extensor connectors and the glove and ankle cuffs match by colour, following the indications in the training materials and instructional videos. Incorrect connection may lead to the patient not receiving the expected clinical benefits. In case of an error, use the barb provided to correct the connection. In case of an error, use the barb provided to correct the connection.

Additional Recommendations:

To ensure the effectiveness and safety of treatment with the NESA XSIGNAL® medical device, it is crucial to familiarize oneself with the color-coding system and carefully follow the connection instructions. Proper handling of the cables and accessories guarantees an optimal therapy experience for the patient.

These guidelines are formulated to aid equipment users in the correct handling of cables and accessories, thereby maximizing treatment efficacy and enhancing patient comfort.

The GDCN Directional Cable (Ref.: C0013) is a vital component of NESA® Non-Invasive Neuromodulation technology. This cable plays a critical role in precisely directing and applying microcurrent therapy, ensuring that treatment is effective and tailored to the patient's needs.

Main Features:

Length: The cable is 2 meters long, providing flexibility and comfort during treatment.

Function: Facilitates precise application of neuromodulation by directing microcurrents to specific treatment areas.

*Frequently Asked Questions on Its Use:

What happens if I do not connect the routing cable?

If the GDCN routing cable is not connected, the neuromodulation treatment will be ineffective. It will result in no treatment effect, with no adverse consequences, but without the expected benefits.

Where do I place the patient directional cable?

The proper placement of the guide wire depends on the treatment goals, the patient's clinical condition, and relevant neuroanatomy. Access to the NESA XSIGNAL® medical device includes a training campus and detailed clinical guidelines that instruct on various treatment possibilities. This training covers clinical reasoning to practical application, ensuring healthcare professionals can deliver therapy effectively and personalized.

Main treatments:

NESA XSIGNAL® medical technology enables a wide range of therapeutic applications. For an overview of the main types of treatment and how to use the GDCN steerable cable effectively, please visit the following link:

Treatments possible with NESA® medical technology. Global, Metameric and Focal 2024. Feat. NESA

Importance of the GDCN routing cable

The GDCN Steering Cable is crucial for the success of NESA® Non-Invasive Neuromodulation therapy. Its proper connection and placement guarantee targeted, precise treatment tailored to the patient's individual needs, maximizing therapeutic benefits. The training provided with the device is essential for understanding and effectively applying this innovative technology.

What are disposable dermal directional electrodes (ECGs)?

Dermal disposable directional electrodes (ECG) are key components in NESA® non-invasive neuromodulation technology. Designed for single use only, these electrodes ensure optimal microcurrent transmission during treatment, thanks to their good adhesion and the presence of conductive gel.

References and sizes:

Ref.: ACC0001 - Disposable Dermal Directional Electrodes for Adult, 50 pcs. (HenrySchein) Cl/Ag, 32 mm.

Ref.: ACC0002 - Pediatric Dermal Disposable Directional Electrodes, 50 pcs. (HenrySchein) Cl/Ag, 26 mm.

*Frequently asked questions about its use

Is it possible to use the disposable electrode more than once?

Reusing disposable electrodes is not recommended. To ensure effective therapy transmission and maintain hygiene standards, each electrode should be used only once. This ensures optimal adherence and availability of the necessary conductive gel for treatment.

What should I do if the disposable electrode causes allergy or itching?

Before using the electrodes, it is important to check if you have any known allergies to silver chloride (AgCl), a material commonly used in these products. If you experience any allergic reactions, such as redness or itching, it is advisable to try ECG electrodes from different brands. Not all brands use the same compounds in their electrodes, which may help you find an option that is compatible with your skin.

Additional Recommendations:

Electrode selection: Since reaction to materials can vary from person to person, having a variety of electrode brands on hand can be useful to suit individual patient needs.

Correct use: Be sure to follow the instructions for use provided with the NESA XSIGNAL® electrodes and medical device to maximise treatment efficacy and minimise the risk of adverse reactions.

Dermal disposable addressable electrode pads (ECGs) are essential for the accurate and effective delivery of neuromodulation therapy with the NESA XSIGNAL® medical device, ensuring a safe and comfortable treatment experience for all patients.

What is the NESA XSIGNAL® medical device power supply?

The NESA XSIGNAL® medical device power supply (Ref.: ACC0009) is an essential component designed to ensure the correct operation and safety of the device. With precise technical specifications, this power supply ensures adequate power delivery for optimal operation of the neuromodulation system.

Technical specifications:

Power supply: 5V 1A, CE Sanitary certified.

Input: 100 -240V, 50-60Hz, 0.3 A.

Output: +5V, 2 A.

International adapters: Included for use on all continents.

*Frequently asked questions about its use

Is it possible to use the power supply abroad?

Yes, the NESA XSIGNAL® medical device power supply can be used internationally without inconvenience. It includes international adapters that allow it to be used in different countries, ensuring that you always have the power you need for your device, no matter where you are.

Can I use a different power supply than the one included?

The use of any power supply other than the one supplied with your NESA XSIGNAL® medical device is not recommended. The included power supply is specifically approved as a "Medical Device," ensuring its safety and compatibility. Using an alternative power supply may damage the device and will void the warranty, and any subsequent repairs will not be covered.

Importance of the specific power supply

The NESA XSIGNAL® medical device power supply is not merely an accessory but a critical component that meets stringent safety and efficacy standards for medical devices. Its design and technical specifications are fundamental to the safe and effective performance of the neuromodulation system, ensuring that patients receive the right treatment without risks associated with the power supply.

Additional Recommendations:

Always use the power supply and adapters supplied with your NESA XSIGNAL® medical device.

Keep international adapters in a safe place to ensure their availability when you travel.

In case of damage or loss of the power supply, contact your supplier or NESA WORLD® for a suitable replacement.

By following these guidelines, you can ensure that your NESA XSIGNAL® medical device performs optimally, providing safe and effective neuromodulation treatments anywhere in the world.

What is the NESA XSIGNAL® medical device carrying case?

The NESA XSIGNAL® Carrying Case (Ref.: XS0003) is a storage and transport solution designed specifically for the NESA XSIGNAL® medical device. Manufactured from high-quality materials, this case ensures the protection and ease of movement of your non-invasive neuromodulation equipment.

Main Features:

Material: Made from durable polypropylene with a polystyrene structure in anthracite color.

Manufacturing details: Includes die cutting and JK HD laser marking on the front and base, providing a professional and durable finish.

Lid: Features a 5 mm black PVC lid, machined with UV printing for a sleek appearance and additional protection.

Timer: Equipped with a white MKT timer and a methacrylate identifier.

*Frequently asked questions about its use

Is the NESA XSIGNAL® medical device suitable for transport?

For long journeys: The carrying case is highly recommended for long journeys due to its robustness and superior protection. It is designed to ensure the integrity of the NESA XSIGNAL® and its accessories, protecting them from impact, dust, and moisture during transport.

For short trips: For shorter or everyday trips, it is recommended to use the XSIGNAL® equipment backpack, designed to offer a lighter and more practical solution without compromising the protection of the equipment.

Importance of the suitcase:

The NESA XSIGNAL® carrying case not only facilitates the safe transport of the device and its components but also reflects NESA WORLD®'s commitment to quality and attention to detail. Its custom design and advanced manufacturing features ensure that your neuromodulation equipment is always protected and ready to use, no matter where your professional or personal practice takes you.

Choosing the NESA XSIGNAL® carrying case means choosing the peace of mind that comes with knowing your device is protected with the best possible protection, allowing you to concentrate on providing safe and effective treatments to your patients.

What is the NESA XSIGNAL® medical device carrying backpack?

The NESA XSIGNAL® Carrying Backpack (Ref.: ACC0007) is a carrying solution specifically designed for the NESA XSIGNAL® medical device and its accessories. Crafted with high-quality materials and tailored features for equipment comfort and safety, this backpack is the ideal companion for healthcare professionals on the move.

Main Features:

Material: 600D Polyester 330g/m2, robust and durable.

Dimensions: 360460180 mm, spacious for storing the device and accessories.

Protection: Anti-humidity treatment and black polystyrene D40 with laser die-cutting to cushion and protect the contents.

Design: Thermo WH print on exterior and interior, with reinforced handle seams for durability.

*Frequently asked questions about its use

Is the NESA XSIGNAL® device suitable for transport?

For short trips: Yes, the backpack is ideal for short trips, offering a practical and safe way to carry the device and its accessories. Perfect for day-to-day use by the healthcare professional or for home treatment.

For long journeys: For long journeys where checked luggage is required, we recommend opting for the NESA XSIGNAL® carry case for additional protection.

Is it fully adapted to transport the NESA XSIGNAL® medical device?

Absolutely, the backpack has been designed with the specific needs of the NESA XSIGNAL® device and its accessories in mind. Its use is highly recommended for healthcare professionals who need mobility without compromising the safety of the equipment. Ideal for personal use after work, weekends for recovery, home treatment, or patient rentals.

Importance of the transport rucksack

The NESA XSIGNAL® carrying backpack not only makes it easy to transport the device and its components safely and comfortably, but also reflects NESA WORLD®'s commitment to quality and functionality. Its customised design and protective features ensure that your neuromodulation equipment is always ready and in perfect condition, allowing you to concentrate on providing the best care for your patients.

Opting for the NESA XSIGNAL® backpack is choosing comfort and safety, ensuring that your device is protected and accessible, no matter where your professional or personal practice takes it.

What is the NESA XSIGNAL® body protection cover?

The NESA XSIGNAL® Body Protection Case (Ref.: ACC0004) is an accessory specifically designed to provide an extra layer of protection for the NESA XSIGNAL® medical device. This case combines functionality and style to ensure that your equipment remains safe and in optimum condition, even in the most demanding environments.

Main Features:

Outer material: Made of high-quality black leatherette, providing durability and resistance to the cover.

Interior: The interior is lined with soft black velvet, with AK2 laser die-cutting to ensure a snug fit around the body of the device, protecting it from scratches and bumps.

UV marking: The cover has a two-zone UV marking in white (WH2), adding an elegant and distinctive touch to the design.

*Frequently Asked Questions on Its Use:

Is it advisable to use the NESA XSIGNAL® protective cover?

Yes, it is advisable to use the protective cover for the NESA XSIGNAL® medical device. Although the device is designed to be rugged and suitable for active use, the protective sleeve provides an additional layer of safety against accidental drops, bumps, or any other incidents that may occur in the working environment, such as on furniture or stretchers. Using the protective case helps to keep the device in the best possible condition, prolonging its lifespan, and ensuring optimal performance.

The NESA XSIGNAL® medical device customized cabinet (Ref.: ACC0011) is a storage and mobility solution specifically designed to complement and facilitate the use of the device in clinical environments. It combines functionality and design to offer an efficient and aesthetically pleasing workstation.

Main Features:

Dimensions: 855mm high x 355mm wide x 355mm deep, providing ample and organised space for the device and its accessories.

Finish: Lacquered in white melamine, offering a smooth surface, easy to clean and resistant to daily use.

Mobility: Equipped with trolley wheels, it allows easy movement within the clinic, adapting to the needs of space and use.

Functionality: Includes sturdy hangers, ideal for organising cables and accessories, keeping the work area tidy and accessible.

*Frequently asked questions about its use

Can the adapted furniture be moved?

Yes, the furniture adapted for the NESA XSIGNAL® device has been meticulously designed with mobility and flexibility in mind within the clinical environment. Its high-quality wheels enable easy movement to any area of the clinic, facilitating the adaptation of space according to treatment needs and patient comfort.

Importance of adapted furniture

The custom NESA XSIGNAL® device cabinet not only offers a practical solution for storing and mobilizing the device and its accessories but also enhances workspace efficiency. Its tailored design ensures that everything required for the application of non-invasive neuromodulation is organized and easily accessible, optimizing workflow and treatment experience for both practitioner and patient.

What is the electrocardiogram included with the purchase of the NESA XSIGNAL® medical device?

The NESA XSIGNAL® incorporates a state-of-the-art portable electrocardiogram (ECG) designed to facilitate detailed heart monitoring and analysis. This compact, advanced device is an essential tool for assessing a patient's cardiovascular health, particularly in the context of neuromodulation.

Technical highlights:

Reference: ACC0013.
Portability: Ultra-light and compact design (87 x 49 x 7mm, weight 33g) for use in any environment.
Validations: Complies with CE and FDA standards, guaranteeing accuracy and reliability.
Connectivity: Compatible with iOS and Android systems via a supported app, with Bluetooth 4.0 for secure and efficient data transmission

Clinical functionalities:

- Arrhythmia check.
- Assessment of myocardial ischaemia using standard leads (I, II, V1, V2, V4, V6).
- Analysis of heart rate variability (HRV) in time and frequency domains.

*Frequently asked questions about its use

What is the electrocardiogram included with the purchase of the NESA XSIGNAL® medical device used for?

The included electrocardiogram is essential for an objective assessment of the autonomic nervous system (ANS) through the recording of heart rate variability (HRV). This measurement offers valuable data on the patient's cardiovascular condition and response to neuromodulation treatment, providing a clear perspective on the evolution of the ANS.

How is it recommended to use the electrocardiogram during treatment?

To maximize the benefits of treatment with the NESA XSIGNAL® device, it is advisable to conduct a baseline HRV recording at the beginning of treatment, a mid-term recording, and a final recording at the end of treatment. These recordings, when combined with other validated tests, enable the objective quantification of the patient's progress.

Importance of the electrocardiogram in NESA® Non-invasive Neuromodulation:

Incorporating a medically validated electrocardiogram into the NESA XSIGNAL® medical device underscores the commitment to evidence-based healthcare and accurate feedback. This device not only enhances the treatment process with valuable clinical data but also empowers healthcare professionals to adjust and personalize neuromodulation interventions based on the patient's physiological response.

For more information on integrating electrocardiography into your daily clinical practice with the NESA XSIGNAL® medical device, we recommend consulting the specific FAQs on the application of NESA® Non-Invasive Neuromodulation.

What is the tablet and tablet holder included with NESA XSIGNAL®?

The Android tablet included with the NESA XSIGNAL® device (Ref.: ACC0010) is an essential digital tool pre-programmed with necessary software for the electrocardiogram, along with a wide range of videos and informative materials designed to enrich the experience of both the clinical team and patients. The tablet holder, on the other hand, is designed to neatly fit into the NESA XSIGNAL® cabinet, providing a convenient way to view content during treatment.

*Frequently asked questions about its use

What content is included in the Android tablet?

The Android tablet comes loaded with a valuable collection of digital resources, including:

Installation videos: Step-by-step guides to set up the NESA XSIGNAL® device.

Clinical reasoning videos and basic protocols: Educational material to optimize the use of the device.

Reviews from patients and elite athletes: Testimonials demonstrating the effectiveness of non-invasive neuromodulation.

3D explainer videos: Visual content to better understand the technology and its benefits.

Most of the information is available in the language of the country of marketing:

(ES) Spanish
(EN) English
(PT) Portuguese
(IT) Italian
(DE) German
(FR) French
(NL) Dutch
(RO) Romanian
(PL) Polish

What is not translated is usually in Spanish with English subtitles, or completely in English for clinics and hospitals.

Advertising is always included.

What publicity material is included?

When you purchase the NESA XSIGNAL® Non-Invasive Neuromodulation System, a complete package of marketing material is included, designed to inform, and attract potential patients, as well as to reinforce the professional image of your clinic. This package includes:

NESA® information leaflets: 500 units of printed leaflets, providing essential information about NESA® medical technology in an accessible and attractive way.

NESA® Non-Invasive Neuromodulation Roll up: An 850 mm x 2200 mm roll up, ideal for events or as a display in your clinic.

NESA® wall series vinyl: An easy-to-install 1200 mm ×1865 mm custom wall vinyl that decorates and effectively communicates the presence of NESA® in your establishment.

NESA® Digital Frame: Equipped with pre-installed videos and advertising images, this digital frame enhances the experience in the waiting room or during consultations.

NESA® Authorised Centre Circle: A black PVC badge certifying your clinic as a NESA® Authorised Centre, customisable with your clinic's logo.

*Frequently asked questions about the advertising material

What happens when the diptychs run out, and can I buy more?

Yes, additional information leaflets are readily available from the NESA WORLD® head office.

¿Puedo instalar por mí mismo los vinilos de pared? Can I install the wall stickers myself?

Absolutely. The vinyls use BubbleFree technology for easy, bubble-free installation. Although they are easy to apply, if you prefer to ensure a perfect installation, you can opt for professional services.

What content comes in the digital frame?

The digital frame includes a variety of explanatory advertising about NESA® medical technology, as well as success stories from sports, clinical, and other fields. All pre-installed for your convenience.

How are NESA® approved center circles customized?

The customization is done by sending the vectorized logo of your clinic to NESA WORLD®. After checking the quality, we proceed with the editing, layout, and printing.

Do NESA® approved center circles adhere well?

Yes, they are designed to adhere firmly inside the clinic. For outdoor installations, additional adhesives are recommended to ensure durability.

Importance of advertising material:

The marketing materials included with the NESA XSIGNAL® medical device serve not only to inform and educate patients about the benefits of non-invasive neuromodulation but also to reinforce the professional image of your clinic as an advanced and licensed NESA® Non-Invasive Neuromodulation treatment center. This advertising toolkit is essential to promote your practice and attract a wider audience interested in innovative health solutions.

Personalized advertising material is available in Spain and Portugal, offering a unique opportunity to highlight your clinic and the services it provides with NESA XSIGNAL® medical technology.


We are committed to transparency and integrity in all our interactions. So, if you have any additional questions, you can contact our Customer Service team by completing the following form. We will answer you as soon as possible.

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