XSIGNAL® Neuromodulator

Medical technology from Non-Invasive Neuromodulation NESA®

Do you consider the autonomic nervous system of your patients to be fundamental?

Do you consider the autonomic nervous system of your patients to be key?

Do you consider sleep quality and good cortisol levels as the basis for any regenerative process in your patients?


The NESA XSIGNAL® neuromodulator is a microcurrent emitter equipped with 25 surface electrodes designed to interface with various peripheral nerves while maintaining low impedance.

  • Equipment Classification: Class II (CE0051)
  • Frequency Range: 1 Hz to 15 Hz
  • Voltage: 3 V – 6 V
  • Amperage: 0.1 mA to 0.9 mA
  • Housing Material: Steel
  • Dimensions (mm): 157.5 (L) x 110 (W) x 45.5 (H)
  • Equipment Weight: Approximately 1.2 kg
  • Number of Emitting Electrodes: 24
  • Number of Directional Electrodes: 1
  • Stand-alone Battery: 6000 mA battery providing approximately 8 hours of operation
  • Power Supply: 5V 1st
  • Power Supply: 5V 1st

Class IIa medical device compliant with MDR 2017/745.

Sanitary device class BF in accordance with IEC 60601-1.

European Directive MDD 93/42/EEC.

European Directive 2012/19/EU concerning waste electrical and electronic equipment.

European Directive 2011/65/EU regarding the use of certain hazardous substances.

European Regulation MDR 2017/745 for medical devices.

For more information on certifications in other countries and continents, please consult the technical FAQS area.

NESA XSIGNAL® Non-invasive Neuromodulator components:

  • NESA XSIGNAL® body.
  • Set of CEXT-N electric extenders (4 units marked: Blue, Red, Green, and Yellow).
  • CONTACT-NC support cable set with 6 connectors (4 units marked: Blue, Red, Green, and Yellow).
  • GDCN directional cable (1 unit).
    Dermal conductive electrodes (2 bags of 50 units).
  • Set of Elastane gloves and anklets in compressive model (Size S x2, Size M x2, Size L x2, Size L x2). (Size change available upon request).
  • NESA XSIGNAL® PWR power supply and geographical area adapters.
  • Heavy-duty case for transporting the NESA XSIGNAL®.
  • NESA XSIGNAL® backpack for transporting the NESA XSIGNAL® device.
  • NESA XSIGNAL® instruction manual.
  • NESA XSIGNAL® timer.
  • Adapted furniture with wheels for the NESA XSIGNAL® device.
  • Wecardio portable electrocardiogram.
  • Android tablet with the electrocardiogram APP installed and NESA XSIGNAL® installation videos.
  • Tablet holder adapted for furniture.
  • Voltmeter.
  • Spike tool for detaching electrodes from gloves and anklets.
  • NESA XSIGNAL® equipment treatment manual.
  • Pack of 500 leaflets.
  • Large personalized Roll Up.
  • Digital communication pack for TV, social networks, and audiovisual media.
  • Digital Pack of Website Material.
  • NESA WORLD CLINIC® towels.
  • Personalized circle of authorized center (Clinics or hospital units only).
  • Customized neural synapse vinyl 120 cm x 180 cm. (clinics or hospital units only).

Nervous system rehabilitation units

“Doing things well or doing things excellently is just a matter of details.” – Japanese proverb






Transform your clinical care with NESA Clinics

The concept of NESA Clinics, or Autonomic Nervous System Readaptation Units (ANSRu), provides a robust framework for elevating integrated well-being. Equipped with the knowledge, precise assessment, and effective treatment offered by NESA XSIGNAL® Non-Invasive Neuromodulation technology, the creation of a supportive environment becomes essential.

Immerse yourself in a space meticulously crafted for total comfort —a unique environment where the tools and clinical expertise of healthcare professionals seamlessly integrate, setting a new standard in global, comprehensive patient care. Our advanced methodology enables accurate assessment and diligent follow-up, ensuring a profoundly regenerative therapeutic journey. Innovation, wellness, and effectiveness define each NESA Clinics unit.

Elevate your medical practice and usher in a transformative health future for your patients.

Are you prepared to lead the change with NESA Clinics and become a benchmark in your field?

Customize your space. Learn more here:

Do you have further technical and/or physical questions
about the Non-Invasive Neuromodulator XSIGNAL®?

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NESA® Microcurrents

Discover the mechanisms of action of Non-Invasive Neuromodulation NESA®.


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